Leveraging Deep Learning for Designing Healthcare Analytics Heuristic for Diagnostics.

Healthcare Informatics is a phenomenon being talked about from the early 21st century in the era in which we are living. With evolution of new computing technologies huge amount of data in healthcare is produced opening several research areas. Managing the massiveness of this data is required while extracting knowledge for decision making is the main concern of today. For this task researchers are doing explorations in big data analytics, deep learning (advanced form of machine learning known as deep neural nets), predictive analytics and various other algorithms to bring innovation in healthcare. Through all these innovations happening it is not wrong to establish that disease prediction with anticipation of its cure is no longer unrealistic. First, Dengue Fever (DF) and then Covid-19 likewise are new outbreak in infectious lethal diseases and diagnosing at all stages is crucial to decrease mortality rate. In case of Diabetes, clinicians and experts are finding challenging the timely diagnosis and analyzing the chances of developing underlying diseases. In this paper, Louvain Mani-Hierarchical Fold Learning healthcare analytics, a hybrid deep learning technique is proposed for medical diagnostics and is tested and validated using real-time dataset of 104 instances of patients with dengue fever made available by Holy Family Hospital, Pakistan and 810 instances found for infectious diseases including prognosis of; Covid-19, SARS, ARDS, Pneumocystis, Streptococcus, Chlamydophila, Klebsiella, Legionella, Lipoid, etc. on GitHub. Louvain Mani-Hierarchical Fold Learning healthcare analytics showed maximum 0.952 correlations between two clusters with Spearman when applied on 240 instances extracted from comorbidities diagnostic data model derived from 15696 endocrine records of multiple visits of 100 patients identified by a unique ID. Accuracy for induced rules is evaluated by Laplace (Fig. 8) as 0.727, 0.701 and 0.203 for 41, 18 and 24 rules, respectively. Endocrine diagnostic data is made available by Shifa International Hospital, Islamabad, Pakistan. Our results show that in future this algorithm may be tested for diagnostics on healthcare big data.

Longitudinal Chest X-ray Scores and their Relations with Clinical Variables and Outcomes in COVID-19 Patients.

Background: This study evaluated the temporal characteristics of lung chest X-ray (CXR) scores in COVID-19 patients during hospitalization and how they relate to other clinical variables and outcomes (alive or dead). Methods: This is a retrospective study of COVID-19 patients. CXR scores of disease severity were analyzed for: (i) survivors (N = 224) versus non-survivors (N = 28) in the general floor group, and (ii) survivors (N = 92) versus non-survivors (N = 56) in the invasive mechanical ventilation (IMV) group. Unpaired t-tests were used to compare survivors and non-survivors and between time points. Comparison across multiple time points used repeated measures ANOVA and corrected for multiple comparisons. Results: For general-floor patients, non-survivor CXR scores were significantly worse at admission compared to those of survivors (p < 0.05), and non-survivor CXR scores deteriorated at outcome (p < 0.05) whereas survivor CXR scores did not (p > 0.05). For IMV patients, survivor and non-survivor CXR scores were similar at intubation (p > 0.05), and both improved at outcome (p < 0.05), with survivor scores showing greater improvement (p < 0.05). Hospitalization and IMV duration were not different between groups (p > 0.05). CXR scores were significantly correlated with lactate dehydrogenase, respiratory rate, D-dimer, C-reactive protein, procalcitonin, ferritin, SpO2, and lymphocyte count (p < 0.05). Conclusions: Longitudinal CXR scores have the potential to provide prognosis, guide treatment, and monitor disease progression.

Classification of Non-Functional Requirements From IoT Oriented Healthcare Requirement Document.

Internet of Things (IoT) involves a set of devices that aids in achieving a smart environment. Healthcare systems, which are IoT-oriented, provide monitoring services of patients' data and help take immediate steps in an emergency. Currently, machine learning-based techniques are adopted to ensure security and other non-functional requirements in smart health care systems. However, no attention is given to classifying the non-functional requirements from requirement documents. The manual process of classifying the non-functional requirements from documents is erroneous and laborious. Missing non-functional requirements in the Requirement Engineering (RE) phase results in IoT oriented healthcare system with compromised security and performance. In this research, an experiment is performed where non-functional requirements are classified from the IoT-oriented healthcare system's requirement document. The machine learning algorithms considered for classification are Logistic Regression (LR), Support Vector Machine (SVM), Multinomial Naive Bayes (MNB), K-Nearest Neighbors (KNN), ensemble, Random Forest (RF), and hybrid KNN rule-based machine learning (ML) algorithms. The results show that our novel hybrid KNN rule-based machine learning algorithm outperforms others by showing an average classification accuracy of 75.9% in classifying non-functional requirements from IoT-oriented healthcare requirement documents. This research is not only novel in its concept of using a machine learning approach for classification of non-functional requirements from IoT-oriented healthcare system requirement documents, but it also proposes a novel hybrid KNN-rule based machine learning algorithm for classification with better accuracy. A new dataset is also created for classification purposes, comprising requirements related to IoT-oriented healthcare systems. However, since this dataset is small and consists of only 104 requirements, this might affect the generalizability of the results of this research.

Predicting COVID-19 Pneumonia Severity on Chest X-ray With Deep Learning.

Introduction The need to streamline patient management for coronavirus disease-19 (COVID-19) has become more pressing than ever. Chest X-rays (CXRs) provide a non-invasive (potentially bedside) tool to monitor the progression of the disease. In this study, we present a severity score prediction model for COVID-19 pneumonia for frontal chest X-ray images. Such a tool can gauge the severity of COVID-19 lung infections (and pneumonia in general) that can be used for escalation or de-escalation of care as well as monitoring treatment efficacy, especially in the ICU. Methods Images from a public COVID-19 database were scored retrospectively by three blinded experts in terms of the extent of lung involvement as well as the degree of opacity. A neural network model that was pre-trained on large (non-COVID-19) chest X-ray datasets is used to construct features for COVID-19 images which are predictive for our task. Results This study finds that training a regression model on a subset of the outputs from this pre-trained chest X-ray model predicts our geographic extent score (range 0-8) with 1.14 mean absolute error (MAE) and our lung opacity score (range 0-6) with 0.78 MAE. Conclusions These results indicate that our model's ability to gauge the severity of COVID-19 lung infections could be used for escalation or de-escalation of care as well as monitoring treatment efficacy, especially in the ICU. To enable follow up work, we make our code, labels, and data available online.

Deep transfer learning artificial intelligence accurately stages COVID-19 lung disease severity on portable chest radiographs.

This study employed deep-learning convolutional neural networks to stage lung disease severity of Coronavirus Disease 2019 (COVID-19) infection on portable chest x-ray (CXR) with radiologist score of disease severity as ground truth. This study consisted of 131 portable CXR from 84 COVID-19 patients (51M 55.1±14.9yo; 29F 60.1±14.3yo; 4 missing information). Three expert chest radiologists scored the left and right lung separately based on the degree of opacity (0-3) and geographic extent (0-4). Deep-learning convolutional neural network (CNN) was used to predict lung disease severity scores. Data were split into 80% training and 20% testing datasets. Correlation analysis between AI-predicted versus radiologist scores were analyzed. Comparison was made with traditional and transfer learning. The average opacity score was 2.52 (range: 0-6) with a standard deviation of 0.25 (9.9%) across three readers. The average geographic extent score was 3.42 (range: 0-8) with a standard deviation of 0.57 (16.7%) across three readers. The inter-rater agreement yielded a Fleiss' Kappa of 0.45 for opacity score and 0.71 for extent score. AI-predicted scores strongly correlated with radiologist scores, with the top model yielding a correlation coefficient (R2) of 0.90 (range: 0.73-0.90 for traditional learning and 0.83-0.90 for transfer learning) and a mean absolute error of 8.5% (ranges: 17.2-21.0% and 8.5%-15.5, respectively). Transfer learning generally performed better. In conclusion, deep-learning CNN accurately stages disease severity on portable chest x-ray of COVID-19 lung infection. This approach may prove useful to stage lung disease severity, prognosticate, and predict treatment response and survival, thereby informing risk management and resource allocation.